Carbamazepine toxicity: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "==Diagnosis==" to "==Evaluation==") |
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==Background== | ==Background== | ||
*Has [[Anticholinergic Toxicity|anticholinergic]] and antiepileptic effects | *Has [[Anticholinergic Toxicity|anticholinergic]] and antiepileptic effects | ||
*Therapeutic concentration: 4-12 | *Therapeutic concentration: 4-12 mg/L | ||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 17:38, 11 August 2016
Background
- Has anticholinergic and antiepileptic effects
- Therapeutic concentration: 4-12 mg/L
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Coma
- Anticholinergic Toxicity
- CV
- Dysrhythmias are rare but may occur
- Wide QRS
- QT Prolongation
Evaluation
- Levels do not accurately correlate with clinical severity
Management
- GI detox
- Activated Charcoal (if presents within 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider discharge for patient with decreasing levels (measured few hrs apart) and is asymptomatic