Bupropion toxicity: Difference between revisions
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==Background== | ==Background== | ||
*Uses | |||
**Antidepressant | |||
**Smoking cessation | |||
**ADHD | |||
*Inhibits reuptake of norepinephrine and dopamine | *Inhibits reuptake of norepinephrine and dopamine | ||
*Toxicity occurs with ingestion of >450mg/d | *Toxicity occurs with ingestion of >450mg/d | ||
Revision as of 03:10, 6 November 2016
Background
- Uses
- Antidepressant
- Smoking cessation
- ADHD
- Inhibits reuptake of norepinephrine and dopamine
- Toxicity occurs with ingestion of >450mg/d
Clinical Features
- Agitation
- Dizziness
- Tremor
- Nausea/vomiting
- Drowsiness
- Tachycardia
- Seizure
- May develop in isolation from other symptoms
- Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms
Differential Diagnosis
Evaluation
Management
- GI decontamination
- Consider whole-bowel irrigation for sustained-release formulations
- Seizure Treatment
- Benzos are 1st line
- Barbituates are 2nd line
Disposition
- Consider discharge if asymptomatic after 8hr for regular-release ingestions