Baclofen withdrawal

Background

• Baclofen (Lioresal) is an anti-spasmodic that works on the as a GABA-b agonist
• Primarily used in patients with Multiple Sclerosis, Cerebral Palsy and Spinal Cord injuries
• Often administered intrathecally but does also have an oral formulation
• Withdrawal symptoms thought to be caused by decreased GABA activation

Clinical Features

Baclofen withdrawal especially in the case of acute intrathecal pump failure may lead to:

• High Fevers
• Confusion
• Altered mental status
• Muscle stiffness
• Seizures
• Rhabdomyolysis
• Multiple organ system failure
• Death

Differential Diagnosis

• Sepsis
• Meningitis
• Epilepsy
• Autonomic dysreflexia
• Neuroleptic malignant syndrome
• Malignant hyperthermia

Evaluation

• History and Physical of Baclofen use
• Examination of the pump
• CPK levels
• Electrolytes
• CBC
• LFTs
• Coagulation studies

Management

• High doses of benzodiazepines are the mainstay of treatment
• High dose oral baclofen has been used but has been less effective
• Intrathecal baclofen bolus can be attempted but overdoses are possible with this method
• Dantrolene and cyproheptadine can also be considered but their efficacy is still unproven in this situation.

Disposition

Admit:

• Organ failure
• Status epilepticus
• Pump malfunction
• Fever
• Loss of Consciousness

See Also

• Cerebral palsy
• Baclofen toxicity

References

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514562/ https://www.drugs.com/cdi/baclofen.html http://www.ncbi.nlm.nih.gov/pubmed/9711203 http://www.clineu-journal.com/article/S0303-8467(02)00009-4/abstract https://www.uptodate.com/contents/baclofen-drug-information?source=search_result&search=baclofen&selectedTitle=1~75