Olanzapine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*Acute agitation (associated with schizophrenia or bipolar disorder): | *Acute agitation (associated with schizophrenia or bipolar disorder): Short-acting IM injection: | ||
**Special risk patients: consider lowering dose to 2.5 mg in patients who are debilitated, who have risk of hypotension or who maybe more pharmacodynamically sensitive to olanzapine. | **initial dose: 10 mg IM (consider lowering to 5 or 7.5 mg depending on clinical factors), additional dose of 10 mg IM maybe considered. Allowed 2 hours after the first dose and 4 hours after the second dose to evaluate response (maximum dose: 30 mg/day). | ||
*Schizophrenia | **Special risk patients: consider lowering dose to 2.5 mg IM in patients who are debilitated, who have risk of hypotension or who maybe more pharmacodynamically sensitive to olanzapine. | ||
*Schizophrenia: Oral | |||
**Initial dose 5-10 mg once daily, increase to 10 mg daily by the first week, adjust by 5 mg daily at 1-week interval (maximum dose: 20 mg daily), maintenance dose: 10-20 mg daily. | |||
**Special risk patient: Initial dose: 5 mg once daily in patients who are debilitated, who have risk of hypotension or who maybe more pharmacodynamically sensitive to olanzapine. | |||
*Bipolar I (acute mixed or manic episode): Oral | |||
**Monotherapy: Initial dose: 10-15 mg once daily, increase by 5 mg daily with interval >24 hours, maintenance dose: 5-20 mg daily (maximum dose: 20 mg daily). | |||
**Combination therapy with lithium or valproate: Initial dose 10 mg daily (dose range: 5-20 mg daily) | |||
*Depression: Oral | |||
**Depression associated with bipolar disorder (in combination with fluoxetine): Initial dose: 5 mg once daily, adjust to dose range of 5-12.5 mg daily. | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 16:33, 10 August 2016
Administration
- Type: Antipsychotic, second generation
- Dosage Forms: tablets, solution, suspension
- Routes of Administration: oral, intramuscular
- Common Trade Names: Zyprexa, Zydis
Adult Dosing
- Acute agitation (associated with schizophrenia or bipolar disorder): Short-acting IM injection:
- initial dose: 10 mg IM (consider lowering to 5 or 7.5 mg depending on clinical factors), additional dose of 10 mg IM maybe considered. Allowed 2 hours after the first dose and 4 hours after the second dose to evaluate response (maximum dose: 30 mg/day).
- Special risk patients: consider lowering dose to 2.5 mg IM in patients who are debilitated, who have risk of hypotension or who maybe more pharmacodynamically sensitive to olanzapine.
- Schizophrenia: Oral
- Initial dose 5-10 mg once daily, increase to 10 mg daily by the first week, adjust by 5 mg daily at 1-week interval (maximum dose: 20 mg daily), maintenance dose: 10-20 mg daily.
- Special risk patient: Initial dose: 5 mg once daily in patients who are debilitated, who have risk of hypotension or who maybe more pharmacodynamically sensitive to olanzapine.
- Bipolar I (acute mixed or manic episode): Oral
- Monotherapy: Initial dose: 10-15 mg once daily, increase by 5 mg daily with interval >24 hours, maintenance dose: 5-20 mg daily (maximum dose: 20 mg daily).
- Combination therapy with lithium or valproate: Initial dose 10 mg daily (dose range: 5-20 mg daily)
- Depression: Oral
- Depression associated with bipolar disorder (in combination with fluoxetine): Initial dose: 5 mg once daily, adjust to dose range of 5-12.5 mg daily.
Pediatric Dosing
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: