Dabigatran reversal: Difference between revisions
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==Background== | ==Background== | ||
*If aPTT is totally normal (<1.5x), unlikely that significant drug effect is present | |||
==Reversal Protocol== | ==Reversal Protocol== | ||
#Mild Bleeding | |||
##Local control measures | |||
##Delay next 1-2 dose OR discontinue as appropriate | |||
#Moderate-Severe Bleeding | |||
##Local control measures/surgical intervention | |||
##Symptomatic treatment | |||
##Fluids/blood/monitoring | |||
##Oral charcoal administration (if taken <2hrs before) | |||
##Hemodialysis (removes 60% over 2-3hrs) | |||
#Life-Threatening Bleeding | |||
##All above | |||
##Consider | |||
###rFVIIa | |||
###PCC | |||
==Source== | ==Source== | ||
Hennipin County Guidelines | |||
University of Utah Healthcare Thrombosis Service Guidelines | |||
[[Category:Heme/ | [[Category:Heme/Onc]] | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 18:15, 9 June 2012
Background
- If aPTT is totally normal (<1.5x), unlikely that significant drug effect is present
Reversal Protocol
- Mild Bleeding
- Local control measures
- Delay next 1-2 dose OR discontinue as appropriate
- Moderate-Severe Bleeding
- Local control measures/surgical intervention
- Symptomatic treatment
- Fluids/blood/monitoring
- Oral charcoal administration (if taken <2hrs before)
- Hemodialysis (removes 60% over 2-3hrs)
- Life-Threatening Bleeding
- All above
- Consider
- rFVIIa
- PCC
Source
Hennipin County Guidelines University of Utah Healthcare Thrombosis Service Guidelines