P450: Difference between revisions
(Text replacement - " esp " to " especially ") |
(→Use) |
||
| Line 12: | Line 12: | ||
===Use=== | ===Use=== | ||
*[[Azithromycin]] | *[[Azithromycin]] | ||
*[[Gentamicin | *[[Gentamicin]] | ||
*[[Cephalosporin]], [[aminopenicillins]] | *[[Cephalosporin]], [[aminopenicillins]] | ||
*[[Nitrofurantoin]] | *[[Nitrofurantoin]] | ||
Revision as of 11:05, 24 September 2016
Background
Antimicrobials
Avoid / P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
Significant P450 Inhibitors in General
- Grapefruit juice
- Valproate
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute EtOH
Significant P450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbituates
- St. John's wort
- Chronic EtOH
- Tobacco smoking