Chloroform toxicity: Difference between revisions
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*Solvent used in chemical and pharmaceutical industries | *Solvent used in chemical and pharmaceutical industries | ||
==Mechanism of Toxicity== | ===Mechanism of Toxicity=== | ||
*CNS depressant | *CNS depressant | ||
*Hepatic and renal toxicity via free radical formation | *Hepatic and renal toxicity via free radical formation | ||
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*Coma | *Coma | ||
*Renal/Hepatic impairment | *Renal/Hepatic impairment | ||
==Differential Diagnosis== | |||
==Diagnosis== | ==Diagnosis== | ||
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*Decontamination | *Decontamination | ||
*Avoid sympathomimetics like epinephrine which may trigger arrhythmia | *Avoid sympathomimetics like epinephrine which may trigger arrhythmia | ||
*N-acetylcysteine may minimize renal and hepatic toxicity | *[[N-acetylcysteine]] may minimize renal and hepatic toxicity | ||
==Disposition== | |||
==See Also== | ==See Also== | ||
Revision as of 04:59, 10 April 2017
Background
- Chloroform (Trichloromethane) is a chlorinated hydrocarbon
- Solvent used in chemical and pharmaceutical industries
Mechanism of Toxicity
- CNS depressant
- Hepatic and renal toxicity via free radical formation
- Arrhythmogenesis
- Carcinogenesis
Clinical Presentation
- Nausea
- Vomiting
- Headache
- Confusion
- Cardiac arrhythmia
- Coma
- Renal/Hepatic impairment
Differential Diagnosis
Diagnosis
- Based on clinical presentation
- Specific levels rarely available
Treatment
- Decontamination
- Avoid sympathomimetics like epinephrine which may trigger arrhythmia
- N-acetylcysteine may minimize renal and hepatic toxicity
Disposition
See Also
External Links
References
- Olson, K. Poisoning and Drug Overdose, 1999.