Carvedilol: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Beta-blocker *Dosage Forms: *Routes of Administration: oral *Common Trade Names: Coreg ==Adult Dosing== *3.125-50mg BID ==Pediatric Dosing== ''Safet...") |
Neil.m.young (talk | contribs) (Text replacement - "alpha" to "α") |
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==Mechanism of Action== | ==Mechanism of Action== | ||
*Nonselective beta-blocker with | *Nonselective beta-blocker with α-1 blocking activity | ||
==Comments== | ==Comments== | ||
Revision as of 01:12, 24 July 2017
Administration
- Type: Beta-blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Coreg
Adult Dosing
- 3.125-50mg BID
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: contraindicated in severe liver disease
Contraindications
- Allergy to class/drug
- Cardiogenic shock
- Asthma or other bronchospastic condition
- 2nd or 3rd degree AV block, severe bradycardia, sick sinus
- Severe hepatic impairment
Adverse Reactions
Serious
- AV block, bradyarrhythmia, hypotension
- SJS/TEN
- Aplastic anemia
- Asthma with status asthmaticus
- Intraoperative floppy iris syndrome (?!)
Common
- Bradyarrhythmia, hypotension
- Peripheral edema
- Weight gain, hyperglycemia
- Diarrhea
- Dizziness, fatigue
- Erectile dysfunction
Pharmacology
- Half-life: 7-10h
- Metabolism: Hepatic CYP2D6
- Excretion: Fecal/biliary
Mechanism of Action
- Nonselective beta-blocker with α-1 blocking activity