Hemochromatosis: Difference between revisions
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*[[Diabetes]] due to iron deposition in pancreatic beta cells | *[[Diabetes]] due to iron deposition in pancreatic beta cells | ||
*[[Cardiomyopathy]] | *[[Cardiomyopathy]] | ||
* [[Arthritis]]: knuckles of the second and third fingers most common | *[[Arthritis]]: knuckles of the second and third fingers most common | ||
* Bronzing of the skin | *Bronzing of the skin | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
==Evaluation== | ==Evaluation== | ||
*Serum ferritin: | *Serum ferritin: | ||
** >300 ng/mL in males and postmenopausal women | **>300 ng/mL in males and postmenopausal women | ||
** >150 - 200 ng/mL in premenopausal women | **>150 - 200 ng/mL in premenopausal women | ||
==Management== | ==Management== | ||
*Phlebotomy | *Phlebotomy | ||
Revision as of 01:13, 24 July 2017
Background
- Accumulation of iron in the body
- Most commonly due to hereditary hemochromatosis (HHC) or iron overload from transfusion
- Hereditary hemochromatosis most common in people of Celtic ancestry
- AKA "bronze diabetes"
Clinical Features
- Cirrhosis
- Diabetes due to iron deposition in pancreatic beta cells
- Cardiomyopathy
- Arthritis: knuckles of the second and third fingers most common
- Bronzing of the skin
Differential Diagnosis
Evaluation
- Serum ferritin:
- >300 ng/mL in males and postmenopausal women
- >150 - 200 ng/mL in premenopausal women
Management
- Phlebotomy
- Chelation with deferoxamine