Camphor toxicity: Difference between revisions

No edit summary
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*Seizure, respiratory depression, coma
*Seizure, respiratory depression, coma
*Hepatitis and liver failure
*Hepatitis and liver failure
==Differential Diagnosis==
==Evaluation==


==Management==
==Management==
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*Intubation and mechanical ventilation as needed
*Intubation and mechanical ventilation as needed
*Charcoal not likely effective
*Charcoal not likely effective
==Disposition==


==See Also==
==See Also==
[[Toxicology]]
 


==References==
==References==

Revision as of 05:53, 7 September 2017

Background

  • Common topical agent for pain relief, wart removal, osteoarthritis, cold sores, cough suppression, nasal decongestion
  • FDA limits over the counter preparations to 11%[1]
  • Highly lipophilic, widely and rapidly distributed, symptom onset 5-15 minutes
  • CNS stimulant when ingested

Clinical Features

  • Nausea, vomiting, abdominal pain
  • Oral burning, headache
  • Vertigo, confusion, agitation
  • Seizure, respiratory depression, coma
  • Hepatitis and liver failure

Differential Diagnosis

Evaluation

Management

  • Aggressive supportive care[2]
  • Benzodiazepines for seizure
  • Intubation and mechanical ventilation as needed
  • Charcoal not likely effective

Disposition

See Also

References

  1. United States Food and Drug Administration. Proposed rules: external analgesic drug products for over-the-counter human use; tentative final monograph. Fed Reg 1983
  2. American Academy of Pediatrics Policy Statement. Camphor Revisited: Focus on Toxicity (RE9422). Pediatrics 1994;94:127-128