Amphetamines: Difference between revisions
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*Increases serotonin, dopamine | *Increases serotonin, dopamine | ||
*Lasts 3 - 5hrs | *Lasts 3 - 5hrs | ||
*Hyponatremia | *[[Hyponatremia]] | ||
==Diagnosis== | ==Diagnosis== | ||
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==Treatment== | ==Treatment== | ||
* | *Benzodiazepines | ||
==See Also== | ==See Also== | ||
*[[ | *[[Toxicology (Main)]] | ||
*PiKHAL: A Chemical Love Story by Alexander Schulgin | *PiKHAL: A Chemical Love Story by Alexander Schulgin | ||
Revision as of 21:59, 11 January 2014
Background
- Class of xenobiotics (Substituted amphetamines) based on a common central structure (ethylamine group attached to a phenol ring)
- All have mixed serotonergic and dopaminergic activity
- Unlike cocaine, duration of action may be 12hr or longer
- Time- oral- 30min, inhaled instant
- hepatic and renal excretion- lasts 6- 24 hrs
- if tolerance developes- physical exam may yield normal findings
- desipramine and amantadine can give false positive for urine amphet test
- hallucinogenic amphetamine derivatives may not show up on tox screen AKA Entactogens- enabling user to touch within
Methamphetamine
- More combative
- Delusions of parasites, formication, self-mutilate
- more dysphoric
MDMA Ecstacy
- Increases serotonin, dopamine
- Lasts 3 - 5hrs
- Hyponatremia
Diagnosis
Alpha
- pupils dilate
- sweat
- decrease gi peristalsis
- constrict blood vessels
Beta
- inc HR and contractility
- dilate bronchi
- dilate muscle beds
Mixed
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion
Treatment
- Benzodiazepines
See Also
- Toxicology (Main)
- PiKHAL: A Chemical Love Story by Alexander Schulgin