Cephalexin: Difference between revisions
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==Kinetics== | ==Kinetics== | ||
*Half-life: 1h (~20hr | *Half-life: 1h (~20hr ESRD) | ||
*Metabolism: Minimal | *Metabolism: Minimal | ||
*Excretion: Primarily urine (>90% unchanged) | *Excretion: Primarily urine (>90% unchanged) | ||
Revision as of 07:29, 5 February 2014
General
- Type: 1st generation cephalosporin
- Dosage forms
- Tabs: 250mg, 500mg, 750mg
- Liquid: 125mg/5mL; 250mg/5mL
Adult Dosing
General
250-500mg PO q6h
Strep Pharyngitis
500mg PO q12h x 10 days
Uncomplicated UTI
500mg PO q12h x 7-14 days
Cellulitis and Other Skin Infections
500mg PO q12h
Pediatric Dosing
General
- 25-50 mg/kg/day PO divided q6-12h
Otitis Media
- 75-100 mg/kg/day PO divided q12h x 10 days
- Max: 4,000 mg/24h
Community Acquired Pneumonia
- 75-100 mg/kg/day PO divided q12h x 10 days
Contraindications
Mechanism of Action
- Bactericidal
- Inhibits cell wall
Adverse Drug Reactions
- Caution advised with contraceptives
Kinetics
- Half-life: 1h (~20hr ESRD)
- Metabolism: Minimal
- Excretion: Primarily urine (>90% unchanged)
Pregnancy/Lactation
- Pregnancy = B
- Lactation = Safe
Overdose Management
Max: 4,000 mg/day
IV Info
See Also
Source
- Sanford 2010
- Epocrates