Cephalexin: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
==Adverse Drug Reactions== | ==Adverse Drug Reactions== | ||
*Caution advised with contraceptives | *Caution advised with contraceptives | ||
== | ==Pharmacology== | ||
*Half-life: 1h (~20hr ESRD) | *Half-life: 1h (~20hr ESRD) | ||
*Metabolism: Minimal | *Metabolism: Minimal | ||
*Excretion: Primarily urine (>90% unchanged) | *Excretion: Primarily urine (>90% unchanged) | ||
*Mechanism of Action: | |||
**Bactericidal, inhibits cell wall | |||
==Pregnancy/Lactation== | ==Pregnancy/Lactation== | ||
*Pregnancy | *Pregnancy: B | ||
*Lactation | *Lactation: Safe | ||
==See Also== | ==See Also== | ||
Revision as of 07:45, 5 February 2014
General
- Type: 1st generation cephalosporin
- Dosage forms
- Tabs: 250mg, 500mg, 750mg
- Liquid: 125mg/5mL; 250mg/5mL
- Common Trade Names: Keflex
Adult Dosing
General
250-500mg PO q6h
Strep Pharyngitis
500mg PO q12h x 10 days
Uncomplicated UTI
500mg PO q12h x 7-14 days
Cellulitis and Other Skin Infections
500mg PO q12h
Pediatric Dosing
General
- 25-50 mg/kg/day PO divided q6-12h
Otitis Media
- 75-100 mg/kg/day PO divided q12h x 10 days
- Max: 4,000 mg/24h
Community Acquired Pneumonia
- 75-100 mg/kg/day PO divided q12h x 10 days
Contraindications
Adverse Drug Reactions
- Caution advised with contraceptives
Pharmacology
- Half-life: 1h (~20hr ESRD)
- Metabolism: Minimal
- Excretion: Primarily urine (>90% unchanged)
- Mechanism of Action:
- Bactericidal, inhibits cell wall
Pregnancy/Lactation
- Pregnancy: B
- Lactation: Safe
See Also
Source
- Sanford 2010
- Epocrates