Cephalosporins: Difference between revisions

Revision as of 23:41, 10 February 2014

1st Gen Cephalosporins
- Cefazolin, Cephalexin
  - Skin and soft tissue infections (why is agent of choice before gen sx)
- Cross-reactivity of PCN allergy <10%
2nd Gen Cephalosporins
- Cefuroxime
  - Intestinal anaerobes (why is agent of chioce for colorectal sx)
  - Largely displaced by 3rd gen agents
3rd Gen Cephalosporins
- Ceftriaxone, Ceftazidime, Cefixime
  - Drug of choice for serious infections due to:
    - Klebsiella
    - Enterobacter
    - Proteus
    - Haemophilus
  - Gonorrhea
  - Lyme disease
  - Meningitis (+ vanc and ampicillin)
  - Pseudomonas meningitis (+ AG)
4th Gen Cephalosporins
- Cefepime
  - Resistant, nosocomial infections
Carbapenems
- Imipenem (+ cilastatin), meropenem
  - Cephalosporin-resistant nosocomial bacteria
  - Empirical treatment of serious infections in patients who recently received other b-lactams
Aztreonam
- Antimicrobial activity more closely resembles AG's (only active against gram -)
  - Enterobacter, pseudomonas, H. influenzae, gonococci
  - Little allergic cross-reactivity with B-lactam antibiotics

Goodman & Gilman's Pharmacology

Authors:

@@ Line 1: / Line 1: @@
-{{Template:Cephalosporin Antibiotics}}
+{{Template:Clinically Active Antibiotics}}
+*'''1st Gen [[Cephalosporins]]'''
+** Cefazolin, [[Cephalexin]]
+*** Skin and soft tissue infections (why is agent of choice before gen sx)
+** [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10%
+*'''2nd Gen Cephalosporins'''
+** Cefuroxime
+*** Intestinal anaerobes (why is agent of chioce for colorectal sx)
+*** Largely displaced by 3rd gen agents
+*'''3rd Gen Cephalosporins'''
+** Ceftriaxone, Ceftazidime, Cefixime
+*** Drug of choice for serious infections due to:
+**** Klebsiella
+**** Enterobacter
+**** Proteus
+**** Haemophilus
+*** Gonorrhea
+*** Lyme disease
+*** Meningitis (+ vanc and ampicillin)
+*** Pseudomonas meningitis (+ AG)
+*'''4th Gen Cephalosporins'''
+** Cefepime
+*** Resistant, nosocomial infections
+* Carbapenems
+** Imipenem (+ cilastatin), meropenem
+*** Cephalosporin-resistant nosocomial bacteria
+*** Empirical treatment of serious infections in patients who recently received other b-lactams
+* Aztreonam
+** Antimicrobial activity more closely resembles AG's (only active against gram -)
+*** Enterobacter, pseudomonas, H. influenzae, gonococci
+*** Little allergic cross-reactivity with B-lactam antibiotics
+==See Also==
+*[[Antibiotics (Main)]]
+==Source==
+Goodman & Gilman's Pharmacology
 [[Category:Drugs]]
+[[Category:ID]]