Physostigmine: Difference between revisions
| Line 30: | Line 30: | ||
==Pharmacology== | ==Pharmacology== | ||
* | *Reversible AChE inhibitor, that increases concentration of acetylcholine | ||
*Metabolism | *Indirectly stimulates both nicotinic and muscarinic ACh receptors | ||
*Excretion | *Metabolism via CYP450 | ||
*Excretion minimally via urine | |||
*Onset of action: 15-20min | *Onset of action: 15-20min | ||
Revision as of 19:52, 7 October 2018
General
- Type: acetylcholinesterase inhibitor
- Dosage Forms: IV/IM
- Common Trade Names: Antilirium
Adult Dosing
Anticholinergic toxicity
- 0.5-2mg IV over 5min
Pediatric Dosing
- .02mg/kg repeat every 5-10 minutes until adequate response, max of 2mg
- no faster than .5mg/min
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Side effects: bradycardia, dysrhythmias, cholinergic excess
- Always have atropine at the bedside for bradycardia or cholinergic excess
Pharmacology
- Reversible AChE inhibitor, that increases concentration of acetylcholine
- Indirectly stimulates both nicotinic and muscarinic ACh receptors
- Metabolism via CYP450
- Excretion minimally via urine
- Onset of action: 15-20min