Famciclovir: Difference between revisions
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== | ==Administration== | ||
*Type: | *Type: [[Antiviral]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: Oral | |||
*Common Trade Names: Famvir | *Common Trade Names: Famvir | ||
==Adult Dosing== | ==Adult Dosing== | ||
*150-1000mg PO BID | |||
===[[Herpes zoster oticus]]=== | |||
*500mg TID x 7 days | |||
===[[HSV-1]]=== | ===[[HSV-1]]=== | ||
*500mg PO TID | *500mg PO TID | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''Safety/efficacy not established'' | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug | *[[Drug pregnancy categories|Pregnancy Rating]]: B | ||
*Lactation: | *Lactation risk: Infant risk cannot be ruled out | ||
*Renal | *Renal dosing: reduced dose | ||
*Hepatic dosing: no adjustment for mild-moderate impairment | |||
*Hepatic | |||
*Famvir Pregnancy Registry: 1-888-669-6682 | *Famvir Pregnancy Registry: 1-888-669-6682 | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* | *Neutropenia, thrombocytopenia | ||
*Skin reaction, severe | |||
* | *Hallucinations, delirium | ||
* | |||
===Common=== | ===Common=== | ||
* | *Nausea/vomiting, diarrhea | ||
*Headache | |||
*Fatigue | |||
* | *Elevated AST/ALT | ||
*Pruritus | |||
* | *Paresthesia | ||
* | *Flatulence | ||
* | |||
* | |||
* | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: 2 | *Half-life: 2.3h | ||
*Metabolism: | *Metabolism: Hepatic, CYP450 | ||
*Excretion: | *Excretion: Mostly renal | ||
==Mechanism of Action== | |||
*Inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication | |||
==Comments== | |||
==See Also== | ==See Also== | ||
*[[Herpes simplex]] | |||
==References== | ==References== | ||
Latest revision as of 19:45, 22 September 2019
Administration
- Type: Antiviral
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names: Famvir
Adult Dosing
- 150-1000mg PO BID
Herpes zoster oticus
- 500mg TID x 7 days
HSV-1
- 500mg PO TID
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: reduced dose
- Hepatic dosing: no adjustment for mild-moderate impairment
- Famvir Pregnancy Registry: 1-888-669-6682
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Neutropenia, thrombocytopenia
- Skin reaction, severe
- Hallucinations, delirium
Common
- Nausea/vomiting, diarrhea
- Headache
- Fatigue
- Elevated AST/ALT
- Pruritus
- Paresthesia
- Flatulence
Pharmacology
- Half-life: 2.3h
- Metabolism: Hepatic, CYP450
- Excretion: Mostly renal
Mechanism of Action
- Inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication