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[[File:25C-NBOMe.png|thumbnail|25C-NBOMe]] | |||
==Background== | ==Background== | ||
*2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | *2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine | ||
Revision as of 17:42, 8 November 2014
Background
- 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
- Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime
- Potent partial agonist of 5-HT2A receptor
- Member of new class of toxic phenethylamine derivatives (NBOMe)
- Commonly ingested orally or sublingually; can also be ingested nasally, parenterally, vaginally, rectally
- Dose of 50-200 micrograms causes hallucinogenic effects
- Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours
Clinical Features
- Metallic chemical taste
- Sense of numbness of tongue and mouth
- Euphoria
- Visual/Auditory hallucinations
- Stimulation +/- tremors, bruxism
- Serotonin syndrome (AMS, hyperthermia, rigidity, autonomic instability)
- Confusion
- Agitation
- Vasoconstriction
- Nausea/Vomiting
- Headache
- Palpitations
- Diaphoresis
- Dysuria
- Hypertension
- Generalized seizure
- Mydriasis
- Acute renal failure
- Metabolic acidosis
Workup
- ISTAT
- Urine pregnancy
- CBC, BMP, LFTs, coags, APAP, ASA
- CK
- ECG
- UA
- Tox screen, blood alcohol
- Serum osmoles, urine Na (if hyponatremia present)
- Head CT as indicated
- LP as indicated to rule out meningitis
Treatment
- ABCs
- IV, O2, monitor
- Agitation
- benzos
- haldol
- Seizure:
- benzos
- manage airway as indicated
- Hyperthermia:
- ice packs, cold IVF
Disposition
- Admit pt's with complications of ingestion
Sources
Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.