Mucositis: Difference between revisions
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*Epstein JB, Schubert MM. Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management. Oncology (Williston Park). 2003;17(12):1767-1792. | |||
Revision as of 04:32, 7 January 2021
Background
- One of the most common side effects of cancer treatment with chemotherapy or radiation
- Occurs in almost all cases of head or neck radiation
- 20-80% of people who receive chemotherapy
Clinical features
- Erythema and ulcerations of the mucosal lining of the gastrointestinal tract
- Causes dysphagia, changes in taste, secondary infections, weight loss
- Oral mucositis is associated with increased inpatient hospitalization duration, bacteremia and higher 100‐day mortality.
- GI mucositis is associated with nausea, vomiting, bloating, diarrhea, intestinal cramping and anal pain.
Differential Diagnosis
- Oral candidiasis
- Herpes simplex virus infection
- Acute Graft-versus-Host disease
Evaluation
Workup
Diagnosis
Management
2020 guidelines from Multinational Association of Supportive Care in Cancer and International Society for Oral Oncology (MASCC/ISOO):
- Prevention with multi agent, combination oral care[2]
- Tooth brushing, flossing, mouthwashes (bland rinses, reduce bacterial build‐up) and applying moisturizing agents to the oral mucosal surfaces
- benzydamine mouthwash for prevention
- Topical morphine 0.2% mouthwash
- Honey
- Saline and sodium bicarb rinses
- No strong evidence but relatively harmless, expert opinion level of recommendation
Chewing gum was NOT effective in preventing oral mucositis in pediatrics
Disposition
See Also
External Links
References
- ↑ Daugėlaitė G, Užkuraitytė K, Jagelavičienė E, Filipauskas A. Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas). 2019;55(2):25. Published 2019 Jan 22. doi:10.3390/medicina55020025
- ↑ Elad S, Cheng KKF, Lalla RV, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020;126(19):4423-4431. doi:10.1002/cncr.33100
- Epstein JB, Schubert MM. Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management. Oncology (Williston Park). 2003;17(12):1767-1792.