Template:Anticholinergic Toxicity Treatement: Difference between revisions
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#*Indicated for severe agitation or delirium (esp if unresponsive to [[benzos]]) | #*Indicated for severe agitation or delirium (esp if unresponsive to [[benzos]]) | ||
#*Avoid when cardiac conduction abnormalities are present | #*Avoid when cardiac conduction abnormalities are present | ||
#*Physostigmine | #*[[Physostigmine]] | ||
#**Dosing: 0.5-2mg IV over 5min | #**Dosing: 0.5-2mg IV over 5min | ||
#**Onset of action: 15-20min | #**Onset of action: 15-20min | ||
#**Side effects: bradycardia, dysrhythmias, cholinergic excess | #**Side effects: bradycardia, dysrhythmias, cholinergic excess | ||
#**always have atropine at the bedside for bradycardia or cholinergic excess | #**always have atropine at the bedside for bradycardia or cholinergic excess | ||
Revision as of 21:07, 23 May 2015
Treatment
- GI decon
- Activated Charcoal may be effective even >1hr after ingestion (decreased GI motility)
- Sedation
- Decreases the risk of hyperthermia, rhabdo, traumatic injuries
- Benzos are agents of choice especially increase seizure threshold
- Cholinesterase inhibition
- Indicated for severe agitation or delirium (esp if unresponsive to benzos)
- Avoid when cardiac conduction abnormalities are present
- Physostigmine
- Dosing: 0.5-2mg IV over 5min
- Onset of action: 15-20min
- Side effects: bradycardia, dysrhythmias, cholinergic excess
- always have atropine at the bedside for bradycardia or cholinergic excess