Famciclovir: Difference between revisions
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===Common=== | ===Common=== | ||
*headache | |||
*nausea | |||
*diarrhea | |||
*vomiting | |||
*fatigue | |||
*pruritus | |||
*neutropenia | |||
*abnormal LFTs | |||
*paresthesia | |||
*flatulence | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 21:12, 29 June 2015
General
- Type: DNA polymerase inhibitor
- Dosage Forms: 125, 250, 500 PO
- Common Trade Names: Famvir
Adult Dosing
HSV-1
- 500mg PO TID
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- neutropenia
- thrombocytopenia
- skin rxn, severe
- hallucinations
- delirium
Common
- headache
- nausea
- diarrhea
- vomiting
- fatigue
- pruritus
- neutropenia
- abnormal LFTs
- paresthesia
- flatulence
Pharmacology
- Half-life: 2-3h
- Metabolism: liver, CYP450
- Excretion: urine primarily, feces
- Mechanism of Action: inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication