Metoclopramide: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*pheochromocytoma | |||
*seizure disorder | |||
*GI bleeding or perforation | |||
*GI obstruction | |||
*caution if depression | |||
*caution if Parkinson dz | |||
*caution if NADH methemoglobin reductase deficiency | |||
*caution if HTN | |||
*caution if CHF | |||
*caution if cirrhosis | |||
*caution if dibetes mellitus | |||
*caution if renal impairment | |||
*caution if neonates | |||
*caution if pediatric pts | |||
*caution if elderly pts, esp. female | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
Revision as of 20:24, 30 June 2015
General
- Type: anti-emetic
- Dosage Forms: 5, 10; 5/5 mL; IM; IV
- Common Trade Names: Reglan
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- pheochromocytoma
- seizure disorder
- GI bleeding or perforation
- GI obstruction
- caution if depression
- caution if Parkinson dz
- caution if NADH methemoglobin reductase deficiency
- caution if HTN
- caution if CHF
- caution if cirrhosis
- caution if dibetes mellitus
- caution if renal impairment
- caution if neonates
- caution if pediatric pts
- caution if elderly pts, esp. female
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 5-6h
- Metabolism: liver minimally; CYP450: unknown
- Excretion: urine 85% (20% unchanged), bile/feces 5%
- Mechanism of Action: exact mechanism of action unknown; sensitizes tissues to acetylcholine, stimulating upper GI tract motility; antagonizes central and peripheral dopamine receptors, producing antiemetic effects