Bupropion toxicity: Difference between revisions
No edit summary |
|||
| Line 27: | Line 27: | ||
==Disposition== | ==Disposition== | ||
*Consider discharge if asymptomatic after 8hr for regular-release ingestions | *Consider discharge if asymptomatic after 8hr for regular-release ingestions | ||
==See Also== | |||
==References== | ==References== | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 12:18, 18 July 2015
Background
- Inhibits reuptake of norepinephrine and dopamine
- Toxicity occurs with ingestion of >450mg/d
Clinical Features
- Agitation
- Dizziness
- Tremor
- Nausea/vomiting
- Drowsiness
- Tachycardia
- Seizure
- May develop in isolation from other symptoms
- Develops within first 1-4hr for regular-release, up to 8hr for delayed release forms
Differential Diagnosis
Diagnosis
Treatment
- GI decontamination
- Consider whole-bowel irrigation for sustained-release formulations
- Seizure Treatment
- Benzos are 1st line
- Barbituates are 2nd line
Disposition
- Consider discharge if asymptomatic after 8hr for regular-release ingestions