Jarisch-Herxheimer reaction: Difference between revisions
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*Can also occur following treatment of tick-borne relapsing fever (TBRF) or [[Lyme disease]] | *Can also occur following treatment of tick-borne relapsing fever (TBRF) or [[Lyme disease]] | ||
*Both [[penicillin]] and [[tetracycline]] can induce JHR | *Both [[penicillin]] and [[tetracycline]] can induce JHR | ||
*Resembles bacterial sepsis. | *Resembles bacterial sepsis. | ||
*Tends to occur within two hours of antibiotic administration | *Tends to occur within two hours of antibiotic administration | ||
**Lasts for a few hours or up to a day | **Lasts for a few hours or up to a day | ||
*Mortality rate from JHR in louse-borne relapsing fever (LBRF) in the absence of adequate monitoring and resuscitation measures is ~5%. | |||
== | ==Clinical Features== | ||
* Malaise | * Malaise | ||
* [[Fever]] | * [[Fever]] | ||
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**Tachycardia and hyperventilation are accompanied by hypertension, and then by a drop in blood pressure due to vasodilation and declining peripheral pulse. | **Tachycardia and hyperventilation are accompanied by hypertension, and then by a drop in blood pressure due to vasodilation and declining peripheral pulse. | ||
== | ==Differential Diagnosis== | ||
==Diagnosis== | |||
==Management== | |||
==Disposition== | |||
==See Also== | |||
== | ==References== | ||
<References/> | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:ID]] | [[Category:ID]] | ||
Revision as of 11:58, 22 August 2015
Background
- A systemic reaction caused by reaction to endotoxins released by the death of harmful organisms within the body
- Occurs following antibiotic treatment for a number of spirochetal and bacterial infections (classically described in the treatment of syphilis)
- Can also occur following treatment of tick-borne relapsing fever (TBRF) or Lyme disease
- Both penicillin and tetracycline can induce JHR
- Resembles bacterial sepsis.
- Tends to occur within two hours of antibiotic administration
- Lasts for a few hours or up to a day
- Mortality rate from JHR in louse-borne relapsing fever (LBRF) in the absence of adequate monitoring and resuscitation measures is ~5%.
Clinical Features
- Malaise
- Fever
- Rigors
- Flushing (due to vasodilation)
- [[Hypotension]
- Tachycardia
- Tachycardia and hyperventilation are accompanied by hypertension, and then by a drop in blood pressure due to vasodilation and declining peripheral pulse.