Rho(D) immune globulin: Difference between revisions
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==General== | |||
*Type: | |||
*Dosage Forms: | |||
*Routes of Administration: | |||
*Common Trade Names: | |||
==Adult Dosing== | |||
==Pediatric Dosing== | |||
==Special Populations== | |||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | |||
*[[Lactation risk categories|Lactation risk]]: | |||
*Renal Dosing | |||
**Adult | |||
**Pediatric | |||
*Hepatic Dosing | |||
**Adult | |||
**Pediatric | |||
==Contraindications== | |||
*Allergy to class/drug | |||
*Prior sensitization of mother | |||
*Known Rh-negative father | |||
*Known Rh-negative fetus (from cord blood) | |||
==Adverse Reactions== | |||
===Serious=== | |||
===Common=== | |||
==Pharmacology== | |||
*Half-life: | |||
*Metabolism: | |||
*Excretion: | |||
*Mechanism of Action: | |||
==Comments== | |||
==See Also== | |||
*[[Vaginal Bleeding (Main)]] | |||
==References== | |||
<references/> | |||
[[Category:Drugs]] | |||
[[Category:OB/GYN]] | |||
==Background== | ==Background== | ||
*For fetal maternal hemorrhage | *For fetal maternal hemorrhage | ||
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**--> give 300 microgm IM once and send Kleihauer-Betke test | **--> give 300 microgm IM once and send Kleihauer-Betke test | ||
**--> within 72hrs give additional 300 microgm/15 ml Rh-positive blood | **--> within 72hrs give additional 300 microgm/15 ml Rh-positive blood | ||
Revision as of 07:14, 29 August 2015
General
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Prior sensitization of mother
- Known Rh-negative father
- Known Rh-negative fetus (from cord blood)
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
See Also
References
Background
- For fetal maternal hemorrhage
- Risk = >4-12wks
- Also given to Rh- male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions[1]
Treatment
- 1st Trimester (through 12weeks)
- --> give 50 microgm IM
- (although there is no harm in giving the standard 300 microgram dose, which is more readily available)
- --> give 50 microgm IM
- 2nd & 3rd Trimester
- --> give 300 microgm IM once and send Kleihauer-Betke test
- --> within 72hrs give additional 300 microgm/15 ml Rh-positive blood
- ↑ Miraflor, E, et al. Emergency uncrossmatched transfusion effect on blood type alloantibodies. J Trauma. 2012; 72:48-53.