Gyromitra mushrooms: Difference between revisions
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*Rarely methemoglobinemia | *Rarely methemoglobinemia | ||
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*Supportive care | *Supportive care | ||
*High dose pyridoxine for refractory seizures (5g IV initially) | *High dose pyridoxine for refractory seizures (5g IV initially) | ||
Revision as of 17:40, 31 January 2016
Overview
- Also known as "brain fungi"
- Fruit in the spring and early summer
- Frequently mistaken for morel mushrooms[1]
- Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite
Clinical findings
- GI upset, fatigue, muscle cramps
- Can present with refractory seizures due to GABA deficiency
- Hemolysis usually mild
- Rarely methemoglobinemia
Management
- Supportive care
- High dose pyridoxine for refractory seizures (5g IV initially)
- Avoid phenobarbital, especially in liver failure
- Methylene blue for severe methemoglobinemia
- Folinic acid supplementation (hydrazines inhibit MTHF production)
References
- ↑ Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.