Tacrolimus: Difference between revisions
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Liver transplant rejection prophylaxis=== | |||
*0.15-0.2 mg/kg/day PO divided q12h | |||
*Start: >6h post-transplant; Info: adjust dose based on serum levels | |||
==Special Populations== | ==Special Populations== | ||
Revision as of 03:15, 9 February 2016
Administration
- Type: immunosuppressant
- Dosage Forms: 0.5,1,5
- Routes of Administration: PO, topical, IV
- Common Trade Names:Prograf
Adult Dosing
Heart transplant rejection prophylaxis
- 0.075 mg/kg/day PO divided q12h
- Start: >6h post-transplant; Info: adjust dose based on serum levels
Liver transplant rejection prophylaxis
- 0.1-0.15 mg/kg/day PO divided q12h
- Start: >6h post-transplant; Info: adjust dose based on serum levels
Kidney transplant rejection prophylaxis
- 0.1-0.2 mg/kg/day PO divided q12h
- Start: w/in 24h post-transplant; delay if renal fxn not adequate; Info: adjust dose based on serum levels
Pediatric Dosing
Liver transplant rejection prophylaxis
- 0.15-0.2 mg/kg/day PO divided q12h
- Start: >6h post-transplant; Info: adjust dose based on serum levels
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: