Tacrolimus

Administration

• Type: immunosuppressant
• Dosage Forms: 0.5,1,5
• Routes of Administration: PO, topical, IV
• Common Trade Names:Prograf

Adult Dosing

Heart transplant rejection prophylaxis

• 0.075 mg/kg/day PO divided q12h
• Start: >6h post-transplant; Info: adjust dose based on serum levels

Liver transplant rejection prophylaxis

• 0.1-0.15 mg/kg/day PO divided q12h
• Start: >6h post-transplant; Info: adjust dose based on serum levels

Kidney transplant rejection prophylaxis

• 0.1-0.2 mg/kg/day PO divided q12h
• Start: w/in 24h post-transplant; delay if renal fxn not adequate; Info: adjust dose based on serum levels

Pediatric Dosing

Liver transplant rejection prophylaxis

• 0.15-0.2 mg/kg/day PO divided q12h
• Start: >6h post-transplant; Info: adjust dose based on serum levels

Special Populations

• Pregnancy Rating: Pregnancy Category C
• Lactation risk: possibly unsafe

Renal Dosing

• Adult:
  • kidney transplant: give lowest recommended dose, may consider further dose decr.; postop oliguria: start 6-24h post-transplant; may delay until renal fxn adequate; HD: not defined
  • all other transplants: give lowest recommended dose, may consider further dose decr.; HD: not defined
• Pediatric: give lowest recommended dose, may consider further dose decr.; HD: not defined

Hepatic Dosing

• Adult: give lowest recommended dose, may consider further dose decr.; Child-Pugh Score >10: decr. dose, amount not defined
• Pediatric: give lowest recommended dose, may consider further dose decr.; Child-Pugh Score >10: decr. dose, amount not defined

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion: