Template:HSV-1 antiviral treatment: Difference between revisions
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===Anti-viral Treatment=== | ===Anti-viral Treatment=== | ||
''Treatment does not affect dormant virus in nerve ganglions → recurrent disease remains possible'' | ''Treatment does not affect dormant virus in nerve ganglions → recurrent disease remains possible'' | ||
* | |||
'''Normal Host''' | |||
*Options: | |||
**[[Acyclovir]] 40-80mg/kg PO divided in 3-4 doses for 5-7 days | **[[Acyclovir]] 40-80mg/kg PO divided in 3-4 doses for 5-7 days | ||
***Can also be used as a cream or oral suspension (swish and swallow)<ref name="Mohan">Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.</ref> | ***Can also be used as a cream or oral suspension (swish and swallow)<ref name="Mohan">Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.</ref> | ||
**[[Valacyclovir]] (significantly higher bioavailability than acyclovir) | **[[Valacyclovir]] (significantly higher bioavailability than acyclovir) | ||
**[[Famciclovir]] | **[[Famciclovir]] | ||
'''Immunocompromised''' | |||
*Options: | |||
**[[Acyclovir]] | |||
***5 mg/kg IV (over 1 hours) q8h x 7 days, OR | |||
***400mg PO 5x/day x 14-21 days | |||
**[[Famciclovir]] 500mg PO BID x 7 days, OR | |||
**[[Valacyclovir]] 500mg PO BID x 5-10 days | |||
Revision as of 20:56, 26 April 2016
Anti-viral Treatment
Treatment does not affect dormant virus in nerve ganglions → recurrent disease remains possible
Normal Host
- Options:
- Acyclovir 40-80mg/kg PO divided in 3-4 doses for 5-7 days
- Can also be used as a cream or oral suspension (swish and swallow)[1]
- Valacyclovir (significantly higher bioavailability than acyclovir)
- Famciclovir
- Acyclovir 40-80mg/kg PO divided in 3-4 doses for 5-7 days
Immunocompromised
- Options:
- Acyclovir
- 5 mg/kg IV (over 1 hours) q8h x 7 days, OR
- 400mg PO 5x/day x 14-21 days
- Famciclovir 500mg PO BID x 7 days, OR
- Valacyclovir 500mg PO BID x 5-10 days
- Acyclovir
- ↑ Mohan RPS, Verma S, Singh U, Agarwal N. Acute primary herpetic gingivostomatitis. BMJ Case Reports. 2013;2013:bcr2013200074. doi:10.1136/bcr-2013-200074.