Colchicine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*Flare treatment: Initial: 1.2 mg and then 0.6 mg in an hour (maximum 1.8 mg within 1 hour). In patient receiving prophylaxis treatment wait for 12 h after flare dosing before resuming prophylaxis dose. Do not repeat treatment for at least 3 days (Canadian labelling recommendation) | Gout | ||
*Prophylaxis Treatment: 0.6 mg twice daily (maximum 1.2 mg/day) for 3 months (without tophi) to 6 months (≥1 tophi) after reaching target serum uric acid levels <ref>Khanna D. et al.2012 ACR Guidelines for Management of Gout Part I: Systemic Non-pharmacologic and Pharmacologic Therapeutic Approach to Hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct; 64(10): 1431–1446.</ref> | **Flare treatment: Initial: 1.2 mg and then 0.6 mg in an hour (maximum 1.8 mg within 1 hour). In patient receiving prophylaxis treatment wait for 12 h after flare dosing before resuming prophylaxis dose. Do not repeat treatment for at least 3 days (Canadian labelling recommendation) | ||
**Prophylaxis Treatment: 0.6 mg twice daily (maximum 1.2 mg/day) for 3 months (without tophi) to 6 months (≥1 tophi) after reaching target serum uric acid levels <ref>Khanna D. et al.2012 ACR Guidelines for Management of Gout Part I: Systemic Non-pharmacologic and Pharmacologic Therapeutic Approach to Hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct; 64(10): 1431–1446.</ref> | |||
*Familial Mediterranean Fever (FMF): 1.2 mg to 2.4 mg per day in 1-2 decided dose. Titrate (increase or decrease) 0.3 mg daily increment based on efficacy and adverse effects. | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 12:58, 16 June 2016
Administration
- Type: Antigout
- Dosage Forms: capsules, tablets
- Routes of Administration: Oral
- Common Trade Names: Colcris; Mitigare (US), Jamp-Colchicine, PMS-Colchicine
Adult Dosing
Gout
- Flare treatment: Initial: 1.2 mg and then 0.6 mg in an hour (maximum 1.8 mg within 1 hour). In patient receiving prophylaxis treatment wait for 12 h after flare dosing before resuming prophylaxis dose. Do not repeat treatment for at least 3 days (Canadian labelling recommendation)
- Prophylaxis Treatment: 0.6 mg twice daily (maximum 1.2 mg/day) for 3 months (without tophi) to 6 months (≥1 tophi) after reaching target serum uric acid levels [1]
- Familial Mediterranean Fever (FMF): 1.2 mg to 2.4 mg per day in 1-2 decided dose. Titrate (increase or decrease) 0.3 mg daily increment based on efficacy and adverse effects.
Pediatric Dosing
- Familial Mediterranea Fever (FMF)
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
Comments
See Also
References
- ↑ Khanna D. et al.2012 ACR Guidelines for Management of Gout Part I: Systemic Non-pharmacologic and Pharmacologic Therapeutic Approach to Hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct; 64(10): 1431–1446.