Stevens-Johnson syndrome and toxic epidermal necrolysis: Difference between revisions
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==Background== | ==Background== | ||
*SJS and TEN involve | *SJS and TEN involve immune-complex mediated cell death w/ separation of epidermis from dermis | ||
**SJS involves <10% of BSA | **SJS involves <10% of BSA | ||
**TEN involves >30% of BSA | **TEN involves >30% of BSA | ||
Revision as of 00:42, 18 February 2012
Background
- SJS and TEN involve immune-complex mediated cell death w/ separation of epidermis from dermis
- SJS involves <10% of BSA
- TEN involves >30% of BSA
Diagnosis
- Often have prodrome (fever, URI symptoms, HA, malaise)
- Rash begins suddenly
- Target lesions
- Mucous membranes can be severely affected
- Eye involvement can be severe
- In severe cases, respiratory tract and GI involvement may occur
Work-Up
- CBC
- Chem
- ESR
- CXR
Treatment
- Removal of inciting cause if identified
- Treat shock w/ IV fluids according to burn protocols
Disposition
- Admit to burn unit or ICU
Source
Tintinalli