Granuloma inguinale: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:TropMed" to "Category:Tropical Medicine") |
Neil.m.young (talk | contribs) (Text replacement - "* " to "*") |
||
| Line 1: | Line 1: | ||
==Background== | ==Background== | ||
* "Donovanosis" | *"Donovanosis" | ||
* ''Klebsiella granulomatis'': Intracellular gram negative rod | *''Klebsiella granulomatis'': Intracellular gram negative rod | ||
* [[Sexually transmitted disease]] | *[[Sexually transmitted disease]] | ||
* Tropical and semitropical (India, Papua New Guinea, Australia, Carribean, Africa) | *Tropical and semitropical (India, Papua New Guinea, Australia, Carribean, Africa) | ||
==Clinical Features== | ==Clinical Features== | ||
* Genital/perineal ulcer | *Genital/perineal ulcer | ||
** Chronic, painless, progressive | **Chronic, painless, progressive | ||
** Irregular, clean-based, granulomatous, nodular | **Irregular, clean-based, granulomatous, nodular | ||
** Hard, bleeds easily | **Hard, bleeds easily | ||
** "Beefy red" | **"Beefy red" | ||
* Urethral stenosis | *Urethral stenosis | ||
* Lymphatic obstruction, elephantiasis | *Lymphatic obstruction, elephantiasis | ||
* Hematogenous spread to spleen, lungs, liver, bones, orbits | *Hematogenous spread to spleen, lungs, liver, bones, orbits | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
* [[Chancroid]] | *[[Chancroid]] | ||
* [[Herpes simplex]] | *[[Herpes simplex]] | ||
* [[Lymphogranuloma venereum]] | *[[Lymphogranuloma venereum]] | ||
* [[Syphilis]] | *[[Syphilis]] | ||
==Diagnosis== | ==Diagnosis== | ||
| Line 28: | Line 28: | ||
==Management== | ==Management== | ||
* [[Doxycycline]] 100mg PO BID x 3 weeks or lesion heals | *[[Doxycycline]] 100mg PO BID x 3 weeks or lesion heals | ||
*Alternative: For 3 week duration or until lesion heals | *Alternative: For 3 week duration or until lesion heals | ||
** [[Azithromycin]] 1g PO qweek | **[[Azithromycin]] 1g PO qweek | ||
** [[Ciprofloxacin]] 750mg PO BID | **[[Ciprofloxacin]] 750mg PO BID | ||
** [[Erythromycin]] base 500mg PO QID | **[[Erythromycin]] base 500mg PO QID | ||
** [[Bactrim DS]] (160mg/800mg) PO BID | **[[Bactrim DS]] (160mg/800mg) PO BID | ||
==See Also== | ==See Also== | ||
Revision as of 10:24, 4 July 2016
Background
- "Donovanosis"
- Klebsiella granulomatis: Intracellular gram negative rod
- Sexually transmitted disease
- Tropical and semitropical (India, Papua New Guinea, Australia, Carribean, Africa)
Clinical Features
- Genital/perineal ulcer
- Chronic, painless, progressive
- Irregular, clean-based, granulomatous, nodular
- Hard, bleeds easily
- "Beefy red"
- Urethral stenosis
- Lymphatic obstruction, elephantiasis
- Hematogenous spread to spleen, lungs, liver, bones, orbits
Differential Diagnosis
Diagnosis
Workup
- Microscopy: Donovan bodies
- Short, pleomorphic rods with bipolar staining
- Screen for other STDs
Management
- Doxycycline 100mg PO BID x 3 weeks or lesion heals
- Alternative: For 3 week duration or until lesion heals
- Azithromycin 1g PO qweek
- Ciprofloxacin 750mg PO BID
- Erythromycin base 500mg PO QID
- Bactrim DS (160mg/800mg) PO BID