Cardiac enzymes: Difference between revisions
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==Creatine Phosphokinase== | ==Creatine Phosphokinase== | ||
*can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine | *can be elevated in trauma, [[rhabdo]], hyperthermia, physical activity, renal or endocrine disease, systemic infections | ||
*if patient small with small muscle mass to begin with, total ck may not be elevated- so better to use | *if patient small with small muscle mass to begin with, total ck may not be elevated- so better to use CK index- is ratio of CKMB/ total CK. Elevated if > 3- 5%. | ||
*CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami | *CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami | ||
Revision as of 01:20, 14 July 2016
Types
Cardiac Enzymes Over Time
| Type | Interval (hours) | Peak Elevation (hours) | Return to Normal |
| Myoglobin | 1-4 | 6-7 | 18-24 hours |
| Troponin I | 3-12 | 10-24 | 3-10 days |
| Troponin T | 3-12 | 10-24 | 5-14 days |
| CK-MB | 4-12 | 12-24 | 2-3 days |
| LDH | 8-12 | 24-48 | 10-14 days |
Creatine Phosphokinase
- can be elevated in trauma, rhabdo, hyperthermia, physical activity, renal or endocrine disease, systemic infections
- if patient small with small muscle mass to begin with, total ck may not be elevated- so better to use CK index- is ratio of CKMB/ total CK. Elevated if > 3- 5%.
- CK Mass: with monoclonal antibody techniques, can directly measure ck mb mass as mmcg/L. More sensitive for detection of ami