Meperidine: Difference between revisions
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===General=== | ===General=== | ||
Pain: | Pain: | ||
*50- | *50-150mg PO/SC/IM/IV q3-4h: decrease dose if given IV. Seizure risk if dose > 600mg in 24 hours. | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Pain: | Pain: | ||
1-1.75mg/kg PO/SC/IM q3-4h, max | 1-1.75mg/kg PO/SC/IM q3-4h, max 100mg/dose | ||
Revision as of 14:12, 19 July 2016
General
- Type: opioid
- Dosage Forms: PO, SC,IM,IV
- Common Trade Names: Demerol
Adult Dosing
General
Pain:
- 50-150mg PO/SC/IM/IV q3-4h: decrease dose if given IV. Seizure risk if dose > 600mg in 24 hours.
Pediatric Dosing
Pain: 1-1.75mg/kg PO/SC/IM q3-4h, max 100mg/dose
Special Populations
- Pregnancy Rating: B
- Lactation Risk Categories: safe
- Renal Dosing
- Adult: CrCl 10-50: decrease dose 25%, if CrCl < 10: decrease dose 50%
- Pediatric: CrCl 10-50: decrease dose 25%, if CrCl < 10: decrease dose 50%
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- MAOI use within 14 days
- Respiratory depression
Adverse Reactions
Serious
- Respiratory Depression
- Apnea
- Hypotension
- syncope
- bradycardia
- urinary retention
- Seizures
- anaphylaxis
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- urinary retention
Pharmacology
- Half-life: 3-5 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:binds to various opioid receptors