SIADH: Difference between revisions
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===Essential Criteria<ref>Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. American Journal of Medicine 1957 23 529–542</ref>=== | ===Essential Criteria<ref>Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. American Journal of Medicine 1957 23 529–542</ref>=== | ||
*Effective serum osmolality <275 mOsm/kg | *Effective serum osmolality <275 mOsm/kg | ||
Revision as of 02:48, 25 July 2016
Evaluation
Essential Criteria[1]
- Effective serum osmolality <275 mOsm/kg
- Urine osmolality >100 mOsm/kg at some level of decreased effective osmolality
- Clinical euvolaemia
- Urine sodium concentration >30 mmol/l with normal dietary salt and water intake
- Absence of adrenal, thyroid, pituitary or renal insufficiency
- No recent use of diuretic agents
Supplemental criteria
- Serum uric acid <0.24 mmol/l (<4mg/dl)
- Serum urea <3.6 mmol/l (<21.6mg/dl)
- Failure to correct hyponatraemia after 0.9% saline infusion
- Fractional sodium excretion >0.5%
- Fractional urea excretion >55%
- Fractional uric acid excretion >12%
- Correction of hyponatraemia through fluid restriction
Etiology
- Extensive differential to include categories in CNS disorders, neoplastic, pulmonary, drug-induced
- See more here - eMedicine, etiologies
References
- ↑ Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. American Journal of Medicine 1957 23 529–542