Carbamazepine toxicity: Difference between revisions
| Line 9: | Line 9: | ||
**Ataxia | **Ataxia | ||
**Nystagmus | **Nystagmus | ||
**Seizures | |||
**Coma | **Coma | ||
*[[Anticholinergic Toxicity]] | *[[Anticholinergic Toxicity]] | ||
Revision as of 17:44, 11 August 2016
Background
- Has anticholinergic and antiepileptic effects
- Therapeutic concentration: 4-12 mg/L
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Seizures
- Coma
- Anticholinergic Toxicity
- CV
- Dysrhythmias are rare but may occur
- Wide QRS
- QT Prolongation
Evaluation
- Levels do not accurately correlate with clinical severity
Management
- GI detox
- Activated Charcoal (if presents within 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider discharge for patient with decreasing levels (measured few hrs apart) and is asymptomatic