Drug induced aseptic meningitis
Background
- Abbreviation: DIAM
- Two proposed mechanisms
- Direct meningeal irritation by intrathecal drug
- Hypersensitivity reaction to drug (type III and IV)
Causes
- NSAIDs
- Antibiotics
- IVIGs
- OKT3 monoclonal antibodies
Clinical presentation
- Headache
- Fever
- Nuchal rigidity
- Nausea/vomiting
- General malaise
- Less common symptoms include rash, arthralgia, myalgia, facial edema