Troponin

Background

• during contraction of muscle- thick filaments of myosin slide past thin filaments of actin by calcium mediated atp dependent contraction. Released calcium binds to troponin C, T, and I, which regulate muscle contraction.
• troponins not change in trauma, skeletal muscle dz, exercise, renal failure like ck does.
• troponin C found in all tissue and is not cardiac marker
• troponin T is qualitative assay.
• troponin I is quantitative assay.

Differential Diagnosis

• ACS

False (Non-CAD) Positives

• Pericarditis
• PE
• CHF
• Sepsis
• Dissection
• Arrhythmias
• CVA
• SAH
• Burns
• Renal failure
  • Assume true positive until proven otherwise
• Cardioversion
• Cardiotoxic meds
• Amyloidosis
• Rheumatoid Factor
• Heterophilic antibodies

See Also

• Cardiac Enzymes
• Acute Coronary Syndrome (Main)

Source

Tintinalli