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• 00:57, 18 March 2026 Ostermayer talk contribs created page Crigler-Najjar syndrome (Created page with "Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder of bilirubin metabolism caused by '''absent (type 1) or severely reduced (type 2) UGT1A1 enzyme activity''', resulting in '''severe unconjugated hyperbilirubinemia''' from birth.<ref name="StatPearls">Crigler-Najjar Syndrome. ''StatPearls''. NCBI. 2024.</ref> Type 1 is a '''life-threatening neonatal emergency''' — without aggressive phototherapy and ultimately liver transplantation, the accumulation o...")