Torsemide

Administration

• Type: Loop diuretic
• Dosage Forms:
• Routes of Administration: IV, PO
• Common Trade Names: Demadex

Adult Dosing

40mg furosemide = 20mg torsemide = 1mg bumetanide

• 5-200 mg PO or IV daily. Titrate to effect by doubling dose

Pediatric Dosing

Safety/efficacy not established

Special Populations

• Pregnancy Rating: B
• Lactation risk: Infant risk cannot be ruled out

Renal dosing: no adjustment Hepatic dosing: no adjustment

Contraindications

• Allergy to class/drug
• Anuria

Adverse Reactions

Serious

• Ventricular tachycardia
• SJS/TEN
• Ototoxicity

Common

• Polyuria
• Rhinitis

Pharmacology

• Half-life: 2-4 hours
• Metabolism: P450
• Excretion: Renal

Mechanism of Action

• Loop diuretic: interferes with Na/K/Cl cotransport system, inhibiting reabsorption of Na/Cl in the ascending limb of the loop of Henle

See Also

• Diuretics