Doxylamine

Administration

• Type: Antihistamine
• Dosage Forms:
• Routes of Administration: oral
• Common Trade Names: Unisom

Adult Dosing

• Rhinitis: 7.5-12.5mg PO q4-6h
• Insomnia: 25-50mg PO
• Nausea in pregnancy/hyperemesis gravidarum: 12.5mg q6-8hrs

Pediatric Dosing

Not recommended for children <12 yo due to tendency to paradoxical reactions

• 2-6yo: 1.9 to 3.125 mg q4-6h
• 6-12 yo: 3.75 to 6.25 mg q4-6h

Special Populations

• Pregnancy Rating: A
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing: no adjustment
• Hepatic dosing: no adjustment

Contraindications

• Allergy to class/drug

Adverse Reactions

Common

• Somnolence

Pharmacology

• Half-life: 10-18h
• Metabolism: Hepatic
• Excretion:

Mechanism of Action

• H1-histamine blocker

See Also

• Antihistamines