Griseofulvin

Administration

• Type: Antifungal
• Dosage Forms:
• Routes of Administration: Oral
• Common Trade Names:

Adult Dosing

• 250-1000mg PO daily

Pediatric Dosing

• 13.6-22.7kg: 125-250mg PO daily
• >22.7kg: 250-500mg PO daily

Special Populations

• Pregnancy Rating: B
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing:
• Hepatic dosing:

Contraindications

• Allergy to class/drug
• Hepatocellular failure
• Porphyria
• Pregnancy

Adverse Reactions

Serious

• Acroparesthesia

Common

• Photosensitivity, rash, urticaria
• Nausea/vomiting, diarrhea
• Headache

Pharmacology

• Half-life: 9-22h
• Metabolism: Liver
• Excretion:

Mechanism of Action

• Fungistatic, deposits into keratin precursor cells and inhibits fungal mitosis

See Also

• Antifungals
• Tinea