Template:Antibiotics Open Fracture
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NNT 12.5 to prevent early fracture site infection[1]
Grade I Fracture Options
- Cefazolin (Ancef) 2g IV TID
- Ciprofloxacin 400mg IV BID (avoid in pediatrics)
Grade II/III Fracture Options
- Add Gentamicin 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins
- Once daily dosing has been shown to be safe and effective
- If concern for Clostridium (soil contamination, farm injuries) then consider single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV TID
- ↑ Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.