EBQ:CRASH-2 Trial

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Under Review Journal Club Article
Shakur H, et al. "Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage". The Lancet. 2010. 376(9734):23-32.
PubMed Full text PDF

Clinical Question

Does administration of tranexamic acid reduce the risk of death if administered early in severe trauma?

Conclusion

Tranexamic acid improves survival when administered in less than 3 hrs after injury in patients with significant hemorrhage.

Major Points

Study Design

Inclusion Criteria

Exclusion Criteria

Interventions

Outcome

Primary Outcomes

Secondary Outcomes

Subgroup analysis

Criticisms & Further Discussion

Funding

Sources