Template:Antibiotics Open Fracture
Revision as of 04:53, 18 September 2018 by Rossdonaldson1 (talk | contribs) (→Prophylactic Antibiotics for Open fractures)
Prophylactic Antibiotics for Open fractures[1]
NNT 12.5 to prevent early fracture site infection[2]
Grade I & II Fractures Options
- Cefazolin (Ancef) 2g IV TID
- Ciprofloxacin 400mg IV BID (avoid in pediatrics)
Grade III Fracture Options
- Add Gentamicin 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins
- Once daily dosing has been shown to be safe and effective
- If concern for Clostridium (soil contamination, farm injuries) then consider single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV TID
- ↑ Open Fractures, Prophylactic Antibiotic Use in — Update. https://www.east.org/education/practice-management-guidelines/open-fractures-prophylactic-antibiotic-use-in-update
- ↑ Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.