Fever of unknown origin

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DDX

  1. Infectious disease (22%)
    1. EBV
    2. UTI
    3. Enterovirus
    4. Lyme
    5. Cat-scratch disease
    6. Osteomyelitis
    7. Psittacosis
    8. Rheumatic fever
    9. Crohn's
    10. Bacterial meningitis
  2. Autoimmune (6%)
    1. JRA
    2. SLE
    3. PAN
  3. Malignancy (2%)
    1. Leukemia
    2. Lymphoma
  4. Drug-induced fever (2%)
  5. Factitious (2%)
  6. No Etiology (67%)

Workup

Phase 1

  1. CBC
  2. ESR
  3. TB test
  4. MonoSpot
  5. CXR
  6. BCx
  7. ASLO
  8. ANA
  9. HIV

Phase 2

  1. LP
  2. BCx again
  3. Sinus/mastoid x-ray
  4. Ophtho exam for iridocyclits
  5. CMV, Toxo, Hep A/B, Tularemia, Brucellosis, Leptospirosis, Salmonellosis
  6. LFTs

Phase 3

  1. Abd U/S
  2. Abd CT
  3. Gallium/Indium scanning
  4. UGI series c sbft
  5. Bone marrow
  6. Technetium bone scan

See Also

Source

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