Fever of unknown origin (peds)

Diagnosis

Febrile >14dys (without clear source)

DDx

1. INFECTION
   1. Bacterial
      1. Adenitis
      2. Endocarditis
      3. Mastoiditis
      4. Occult abcess
      5. Pyelonephritis
      6. Sinusitis
      7. Tb
   2. Viral
      1. CMV
      2. Hep A,B, C
      3. Mono
   3. Chlamydial
      1. Lymphogranuloma venereum
      2. Psittacosis
   4. Mycoplasmal
   5. Fungal
      1. Blastomycosis
      2. Cysticercosis
      3. Histoplasmosis
      4. Rickettsial
         1. Q fever
         2. Rocky Mt
      5. Parasitic
         1. Malaria
         2. Toxo
2. COLLAGEN VASCULAR
   1. JRA
   2. LSE
   3. Regional enteritis
   4. Rheumatic fever
   5. Ulcerative colitis
   6. Vasculitis
3. MALIGNANCY
   1. Leukemia
   2. Lymphoma
   3. Neuroblastoma
   4. Wilm's tumor
4. DRUG INDUCED
   1. Abx
   2. Anticonvulsants
   3. Anti TB
   4. Procainamide
   5. Quinidine
   6. Serum sickness
5. MISC
   1. AIDS
   2. CNS
   3. Environmental
   4. Factitious
   5. Familial dysautonomia
   6. Kawasaki
   7. PE
   8. Serial infections
   9. Thyrotoxicosis

Source

4/13/06 DONALDSON (adapted from Rosen)