EBQ:De Gans - Steroids for Bacterial Meningitis

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incomplete Journal Club Article
de Gans JD, et al. "Dexamethasone in Adults with Bacterial Meningitis". The New England Journal of Medicine. 2002. 347(20):1549-1556.
PubMed Full text PDF

Clinical Question

In patients with acute bacterial meningitis does dexamethasone improve outcomes when given in addition to standard antibiotic therapy?

Conclusion

Early treatment with dexamethasone in adults with acute bacterial meningitis improves outcomes. There is no increase in GI bleed.

Major Points

Study Design

Prospective, randomized, double-blinded, multi-center, controlled trial

Population

Patient Demographics

Inclusion Criteria

Exclusion Criteria

Interventions

Outcomes

Primary Outcome

Secondary Outcomes

Subgroup analysis

Criticisms & Further Discussion

Funding

Sources

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