Template:Steroids Bacterial Meningitis
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- The goal of early glucocorticoids for bacterial meningitis, is to reduce the neurologic morbidity, particularly with Streptococcus pneumoniae
- Early animal research demonstrated a decrease in hearing loss in rabbits[1] and shown in adults in Europe to reduce mortality in patient with Streptococcus pneumoniae Meningitis[2]
- However meta-analysis demonstrated no mortality difference overall and only in the subgroup with cultures positive for Streptococcus pneumoniae and not those for [H. Influenza]] or Neisseria meningitidis[3]
- ↑ Bhatt SM et al. Progression of hearing loss in experimental pneumococcal meningitis: correlation with cerebrospinal fluid cytochemistry. J Infect Dis. 1993;167(3):675
- ↑ EBQ:De Gans - Steroids for Bacterial Meningitis
- ↑ Brouwer MC, McIntyre P, de Gans J, Prasad K, van de Beek D. Corticosteroids for Acute Bacterial Meningitis. Cochrane Database of Systematic Reviews 2010, Issue 9.