Template:Warfarin Reversal

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  1. Stop warfarin
  2. Give Vitamin K 5-10mg IV INR will decrease over 24-48 hours (small risk of anaphylaxis with IV Vitamin K)
  3. Give 4 Factor Prothrombin Complex Concentrate (PCC)
  4. If no PCC then give 2 unites Fresh Frozen Plasma
    1. No benefit to combining PCC and FFP
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