Rho(D) immune globulin

Revision as of 23:09, 7 January 2015 by Neil.m.young (talk | contribs)

Background

  • For fetal maternal hemorrhage
  • Risk = >4-12wks
  • Also given to Rh- male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions[1]

Treatment

  1. 1st Trimester (through 12weeks)
    1. --> give 50 microgm IM
      1. (although there is no harm in giving the standard 300 microgram dose, which is more readily available)
  2. 2nd & 3rd Trimester
    1. --> give 300 microgm IM once and send Kleihauer-Betke test
    2. --> within 72hrs give additional 300 microgm/15 ml Rh-positive blood

Exceptions

  1. Prior sensitization of mother
  2. Known Rh-negative father
  3. Known Rh-negative fetus (from cord blood)

See Also

Vaginal Bleeding (Main)

Source

UpToDate

  1. ↑ Miraflor, E, et al. Emergency uncrossmatched transfusion effect on blood type alloantibodies. J Trauma. 2012; 72:48-53.
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